NBRP Rat No: 0729 |
系統名: LEW.WKY-(D13Arb15-D13Rat77)(D16Rat40-D16Rat88)/Tja |
通称: LEW.WCrgn1,2 |
Rat Genome Database |
研究責任者: |
Timothy J. Aitman Medical Research Council 〒W12 0NN London Hammersmith Hospital campus, Du Cane Road United Kingdom |
Tel: +44 20 8383 4253 Fax: +44 20 8383 8577 |
Email: t.aitman@csc.mrc.ac.uk |
保存状況: |
胚 精子 生体 |
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毛色 |
Albino |
近交世代数 |
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利用条件 |
研究成果の公表にあたって寄託者の指定する文献を引用する。
D'Souza Z., McAdoo S.P., Smoth J., Pusey C.D., Cook H.T., Behmoaras J., Aitman T.J. (2013) Experimental crescentic glomerulonephritis: a new bicongenic rat model. Disease Models and Mechanisms. |
分類 |
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コマーシャルブリーダー |
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研究分野 |
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遺伝子 |
Lewis bicongenic (chromosomes 13 and 16) |
由来 |
LEWIS: Lewis from Wistar stock, to Aptekman and Bogden 1954 at F20, to SIlvers 1958 at F31. Subsequently distributed by Silvers. |
特性など |
Development of glomerular crescents, a hallmark of crescentic glomerulonephritis (CRGN) after the induction of nephrotoxic serum in this Lewis-related bicongenic strain, compared to parental Lewis strain which is resistant to CRGN. |
繁殖・維持方法 |
No special needs. Good breeding performance, 6-8 litters, normal diet, water acidification, no supplements, no medications. |
遺伝診断法 |
Microsatellite markers used for genotyping.
Chromosome 13: Congenic locus spans between D13Arb15 to D13Rat77
Chromosome 16: Congenic locus spans between D16Rat40 to D16Rat88 |
参考文献 |
D'Souza et al (2013) Experimental crescentic glomerulonephritis: a new bicongenic rat model. Disease Models and Mechanisms.
Aitman et al (2006) Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans. Nature. 2006 Feb 16;439(7078):851-5.
Behmoaras et al (2008) Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility. Nat Genet. 2008 May;40(5):553-9. doi: 10.1038/ng.137. |
系統情報 |
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