 Tabs(ALL, DNA, BLAST, GO, Taxonomy, DO, Reference) are clickable.
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Reference Related Resource Count: 33,482
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Associated Resources List
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Category: targeted mutation
| Strain Name : |
B6.129P2-Itgal<tm1Mak> |
| Gene : |
Itgal,neo |
| Species : |
Mus musculus |
| Disease : |
Immunology and Inflammation Research,Virology Research,covid19_infection |
| Conditions for use : |
Recovered litters from cryopreserved embryos (2 to 4 months),Cryopreserved embryos (within 1 month) |
| Status : |
Frozen embryos |
| Taxonomy : |
Mus musculus
|
| Reference : |
Saitoh SI, Abe F, Kanno A, Tanimura N, Mori Saitoh Y, Fukui R, Shibata T, Sato K, Ichinohe T, Hayashi M, Kubota K, Kozuka-Hata H, Oyama M, Kikko Y, Katada T, Kontani K, Miyake K. (2017) TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells. Nat Commun 8(1) 1592
Saitoh SI, Abe F, Kanno A, Tanimura N, Mori Saitoh Y, Fukui R, Shibata T, Sato K, Ichinohe T, Hayashi M, Kubota K, Kozuka-Hata H, Oyama M, Kikko Y, Katada T, Kontani K, Miyake K. (2017) TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells. Nat Commun 8(1) 1592
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Category: targeted mutation
| Strain Name : |
B6.129S2-Rbpj<tm1Kyo>/HonRbrc |
| Gene : |
Rbpj,neo |
| Species : |
Mus musculus |
| Disease : |
Developmental Biology Research |
| Conditions for use : |
Recovered litters from cryopreserved embryos (2 to 4 months),Cryopreserved sperm (within 1 month),Cryopreserved embryos (within 1 month) |
| Status : |
Frozen embryos,Frozen sperm |
| Taxonomy : |
Mus musculus
|
| Reference : |
Niwa Y, Masamizu Y, Liu T, Nakayama R, Deng CX, Kageyama R. (2007) The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and notch signaling in the somite segmentation clock. Dev Cell 13(2) 298-304
Niwa Y, Masamizu Y, Liu T, Nakayama R, Deng CX, Kageyama R. (2007) The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and notch signaling in the somite segmentation clock. Dev Cell 13(2) 298-304
|
Category: targeted mutation
| Strain Name : |
B6.Cg-Stab2<tm1> |
| Gene : |
Stab2,neo,lacZ |
| Species : |
Mus musculus |
| Disease : |
Fluorescent Proteins/lacZ System,Hematological Research |
| Conditions for use : |
Recovered litters from cryopreserved embryos (2 to 4 months),Cryopreserved sperm (within 1 month),Cryopreserved embryos (within 1 month) |
| Status : |
Frozen embryos,Frozen sperm |
| Taxonomy : |
Mus musculus
|
| Reference : |
Donner AJ, Wancewicz EV, Murray HM, Greenlee S, Post N, Bell M, Lima WF, Swayze EE, Seth PP. (2017) Co-Administration of an Excipient Oligonucleotide Helps Delineate Pathways of Productive and Nonproductive Uptake of Phosphorothioate Antisense Oligonucleotides in the Liver. Nucleic Acid Ther 27(4) 209-220
Donner AJ, Wancewicz EV, Murray HM, Greenlee S, Post N, Bell M, Lima WF, Swayze EE, Seth PP. (2017) Co-Administration of an Excipient Oligonucleotide Helps Delineate Pathways of Productive and Nonproductive Uptake of Phosphorothioate Antisense Oligonucleotides in the Liver. Nucleic Acid Ther 27(4) 209-220
Pirie E, Ray S, Pan C, Fu W, Powers AF, Polikoff D, Miller CM, Kudrna KM, Harris EN, Lusis AJ, Crooke RM, Lee RG. (2018) Mouse genome-wide association studies and systems genetics uncover the genetic architecture associated with hepatic pharmacokinetic and pharmacodynamic properties of a constrained ethyl antisense oligonucleotide targeting Malat1. PLoS Genet 14(10) e1007732
Pirie E, Ray S, Pan C, Fu W, Powers AF, Polikoff D, Miller CM, Kudrna KM, Harris EN, Lusis AJ, Crooke RM, Lee RG. (2018) Mouse genome-wide association studies and systems genetics uncover the genetic architecture associated with hepatic pharmacokinetic and pharmacodynamic properties of a constrained ethyl antisense oligonucleotide targeting Malat1. PLoS Genet 14(10) e1007732
|
Category: targeted mutation
| Strain Name : |
B6.129X1-Chrng<tm1Mtak>/10Rbrc |
| Gene : |
Chrng,neo |
| Species : |
Mus musculus |
| Disease : |
Neurobiology Research |
| Conditions for use : |
Recovered litters from cryopreserved embryos (2 to 4 months),Cryopreserved embryos (within 1 month) |
| Status : |
Frozen embryos |
| Taxonomy : |
Mus musculus
|
| Reference : |
Liu Y, Padgett D, Takahashi M, Li H, Sayeed A, Teichert RW, Olivera BM, McArdle JJ, Green WN, Lin W. (2008) Essential roles of the acetylcholine receptor gamma-subunit in neuromuscular synaptic patterning. Development 135(11) 1957-67
Liu Y, Padgett D, Takahashi M, Li H, Sayeed A, Teichert RW, Olivera BM, McArdle JJ, Green WN, Lin W. (2008) Essential roles of the acetylcholine receptor gamma-subunit in neuromuscular synaptic patterning. Development 135(11) 1957-67
|
Category: targeted mutation
| Strain Name : |
B6.129S-Grm2<tm1Nak>/NakRbrc |
| Gene : |
Grm2,neo |
| Species : |
Mus musculus |
| Disease : |
Neurobiology Research |
| Conditions for use : |
Recovered litters from cryopreserved embryos (2 to 4 months),Cryopreserved sperm (within 1 month),Cryopreserved embryos (within 1 month) |
| Status : |
Frozen embryos,Frozen sperm |
| Taxonomy : |
Mus musculus
|
| Reference : |
Moreno JL, Holloway T, Albizu L, Sealfon SC, González-Maeso J. (2011) Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists. Neurosci Lett 493(3) 76-9
Moreno JL, Holloway T, Albizu L, Sealfon SC, González-Maeso J. (2011) Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists. Neurosci Lett 493(3) 76-9
Moreno JL, Muguruza C, Umali A, Mortillo S, Holloway T, Pilar-Cuéllar F, Mocci G, Seto J, Callado LF, Neve RL, Milligan G, Sealfon SC, López-Giménez JF, Meana JJ, Benson DL, González-Maeso J. (2012) Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A·mGlu2) receptor heteromerization and its psychoactive behavioral function. J Biol Chem 287(53) 44301-19
Moreno JL, Muguruza C, Umali A, Mortillo S, Holloway T, Pilar-Cuéllar F, Mocci G, Seto J, Callado LF, Neve RL, Milligan G, Sealfon SC, López-Giménez JF, Meana JJ, Benson DL, González-Maeso J. (2012) Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A·mGlu2) receptor heteromerization and its psychoactive behavioral function. J Biol Chem 287(53) 44301-19
Fribourg M, Moreno JL, Holloway T, Provasi D, Baki L, Mahajan R, Park G, Adney SK, Hatcher C, Eltit JM, Ruta JD, Albizu L, Li Z, Umali A, Shim J, Fabiato A, MacKerell AD Jr, Brezina V, Sealfon SC, Filizola M, González-Maeso J, Logothetis DE. (2011) Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs. Cell 147(5) 1011-23
Fribourg M, Moreno JL, Holloway T, Provasi D, Baki L, Mahajan R, Park G, Adney SK, Hatcher C, Eltit JM, Ruta JD, Albizu L, Li Z, Umali A, Shim J, Fabiato A, MacKerell AD Jr, Brezina V, Sealfon SC, Filizola M, González-Maeso J, Logothetis DE. (2011) Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs. Cell 147(5) 1011-23
Moreno JL, Holloway T, Rayannavar V, Sealfon SC, González-Maeso J. (2013) Chronic treatment with LY341495 decreases 5-HT(2A) receptor binding and hallucinogenic effects of LSD in mice. Neurosci Lett 536 69-73
Moreno JL, Holloway T, Rayannavar V, Sealfon SC, González-Maeso J. (2013) Chronic treatment with LY341495 decreases 5-HT(2A) receptor binding and hallucinogenic effects of LSD in mice. Neurosci Lett 536 69-73
Moreno JL, Miranda-Azpiazu P, García-Bea A, Younkin J, Cui M, Kozlenkov A, Ben-Ezra A, Voloudakis G, Fakira AK, Baki L, Ge Y, Georgakopoulos A, Morón JA, Milligan G, López-Giménez JF, Robakis NK, Logothetis DE, Meana JJ, González-Maeso J. (2016) Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia. Sci Signal 9(410) ra5
Moreno JL, Miranda-Azpiazu P, García-Bea A, Younkin J, Cui M, Kozlenkov A, Ben-Ezra A, Voloudakis G, Fakira AK, Baki L, Ge Y, Georgakopoulos A, Morón JA, Milligan G, López-Giménez JF, Robakis NK, Logothetis DE, Meana JJ, González-Maeso J. (2016) Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia. Sci Signal 9(410) ra5
Kim H, Lee Y, Park JY, Kim JE, Kim TK, Choi J, Lee JE, Lee EH, Kim D, Kim KS, Han PL. (2017) Loss of Adenylyl Cyclase Type-5 in the Dorsal Striatum Produces Autistic-Like Behaviors. Mol Neurobiol 54(10) 7994-8008
Kim H, Lee Y, Park JY, Kim JE, Kim TK, Choi J, Lee JE, Lee EH, Kim D, Kim KS, Han PL. (2017) Loss of Adenylyl Cyclase Type-5 in the Dorsal Striatum Produces Autistic-Like Behaviors. Mol Neurobiol 54(10) 7994-8008
|
Category: congenic strain
Category: targeted mutation
| Strain Name : |
C.Cg-Tnc<tm1Sia>/Rbrc |
| Gene : |
Tnc,lacZ,neo |
| Species : |
Mus musculus |
| Conditions for use : |
Recovered litters from cryopreserved embryos (2 to 4 months),Cryopreserved sperm (within 1 month),Cryopreserved embryos (within 1 month) |
| Status : |
Frozen embryos,Frozen sperm |
| Taxonomy : |
Mus musculus
|
| Reference : |
Kobayashi Y, Yoshida S, Zhou Y, Nakama T, Ishikawa K, Kubo Y, Arima M, Nakao S, Hisatomi T, Ikeda Y, Matsuda A, Sonoda KH, Ishibashi T. (2016) Tenascin-C secreted by transdifferentiated retinal pigment epithelial cells promotes choroidal neovascularization via integrin αV. Lab Invest 96(11) 1178-1188
Kobayashi Y, Yoshida S, Zhou Y, Nakama T, Ishikawa K, Kubo Y, Arima M, Nakao S, Hisatomi T, Ikeda Y, Matsuda A, Sonoda KH, Ishibashi T. (2016) Tenascin-C secreted by transdifferentiated retinal pigment epithelial cells promotes choroidal neovascularization via integrin αV. Lab Invest 96(11) 1178-1188
|
Category: spontaneous mutation
| Strain Name : |
C3H/HeSn-Ttf/+tf |
| Gene : |
Itpr3,T |
| Species : |
Mus musculus |
| Disease : |
Dermatology Research,Developmental Biology Research |
| Conditions for use : |
Recovered litters from cryopreserved embryos (2 to 4 months),Cryopreserved embryos (within 1 month) |
| Status : |
Frozen embryos |
| Taxonomy : |
Mus musculus
|
| Reference : |
Hatakeyama Y, Saito N, Mii Y, Takada R, Shinozuka T, Takemoto T, Naoki H, Takada S. (2023) Intercellular exchange of Wnt ligands reduces cell population heterogeneity during embryogenesis. Nat Commun 14(1) 1924
Hatakeyama Y, Saito N, Mii Y, Takada R, Shinozuka T, Takemoto T, Naoki H, Takada S. (2023) Intercellular exchange of Wnt ligands reduces cell population heterogeneity during embryogenesis. Nat Commun 14(1) 1924
|
Category: congenic strain
| Strain Name : |
B6.SJL-Ptprc<a>/Rbrc |
| Gene : |
Ptprc |
| Species : |
Mus musculus |
| Disease : |
Immunology and Inflammation Research |
| Conditions for use : |
Live mouse (1 to 3 months),Cryopreserved sperm (within 1 month),Cryopreserved embryos (within 1 month) |
| Status : |
Live mice,Frozen embryos,Frozen sperm |
| Taxonomy : |
Mus musculus
|
| Reference : |
Yo M, Sakaue-Sawano A, Noda S, Miyawaki A, Miyoshi H. (2015) Fucci-guided purification of hematopoietic stem cells with high repopulating activity. Biochem Biophys Res Commun 457(1) 7-11
Tanaka Y, Nagashima H, Bando K, Lu L, Ozaki A, Morita Y, Fukumoto S, Ishii N, Sugawara S. (2017) Oral CD103
Nakashima K, Arai S, Suzuki A, Nariai Y, Urano T, Nakayama M, Ohara O, Yamamura K, Yamamoto K, Miyazaki T. (2013) PAD4 regulates proliferation of multipotent haematopoietic cells by controlling c-myc expression. Nat Commun 4 1836
Omi A, Enomoto Y, Kiniwa T, Miyata N, Miyajima A. (2014) Mature resting Ly6C(high) natural killer cells can be reactivated by IL-15. Eur J Immunol 44(9) 2638-47
Kondo T, Ikegawa S, Fukumi T, Sumii Y, Sugiura H, Sando Y, Nakamura M, Meguri Y, Iwamoto M, Maeda Y, Matsuoka KI. (2021) Pretransplant Short-Term Exposure of Donor Graft Cells to ITK Selective Inhibitor Ameliorates Acute Graft-versus-Host Disease by Inhibiting Effector T Cell Differentiation while Sparing Regulatory T Cells. Immunohorizons 5(6) 424-437
Hosaka N, Kanda S, Shimono T, Nishiyama T. (2021) Induction of γδT cells from HSC-enriched BMCs co-cultured with iPSC-derived thymic epithelial cells. J Cell Mol Med 25(22) 10604-10613
Satoh T, Tajima M, Wakita D, Kitamura H, Nishimura T. (2012) The development of IL-17/IFN-γ-double producing CTLs from Tc17 cells is driven by epigenetic suppression of Socs3 gene promoter. Eur J Immunol 42(9) 2329-42
Mise-Omata S, Alles N, Fukazawa T, Aoki K, Ohya K, Jimi E, Obata Y, Doi T. (2014) NF-κB RELA-deficient bone marrow macrophages fail to support bone formation and to maintain the hematopoietic niche after lethal irradiation and stem cell transplantation. Int Immunol 26(11) 607-18
Sumii Y, Kondo T, Ikegawa S, Fukumi T, Iwamoto M, Nishimura MF, Sugiura H, Sando Y, Nakamura M, Meguri Y, Matsushita T, Tanimine N, Kimura M, Asada N, Ennishi D, Maeda Y, Matsuoka KI. (2023) Hematopoietic stem cell-derived Tregs are essential for maintaining favorable B cell lymphopoiesis following posttransplant cyclophosphamide. JCI Insight 8(8)
Suga K, Suto A, Tanaka S, Sugawara Y, Kageyama T, Ishikawa J, Sanayama Y, Ikeda K, Furuta S, Kagami SI, Iwata A, Hirose K, Suzuki K, Ohara O, Nakajima H. (2023) TAp63, a methotrexate target in CD4+ T cells, suppresses Foxp3 expression and exacerbates autoimmune arthritis. JCI Insight 8(10)
Takahiro Sano, Koki Ueda, Keiji Minakawa, Tsutomu Mori, Yuko Hashimoto, Haruhiko Koseki, Yasuchika Takeishi, Kazuhiko Ikeda, Takayuki Ikezoe (2023) Impaired Repopulating Ability of Uhrf2−/− Hematopoietic Progenitor Cells in Mice Genes 14 1531
Mise-Omata S, Ando M, Srirat T, Nakagawara K, Hayakawa T, Iizuka-Koga M, Nishimasu H, Nureki O, Ito M, Yoshimura A. (2023) SOCS3 deletion in effector T cells confers an anti-tumorigenic role of IL-6 to the pro-tumorigenic cytokine. Cell Rep 112940
Tajima M, Wakita D, Satoh T, Kitamura H, Nishimura T. (2011) IL-17/IFN-γ double producing CD8+ T (Tc17/IFN-γ) cells: a novel cytotoxic T-cell subset converted from Tc17 cells by IL-12. Int Immunol 23(12) 751-9
By Yukiko Tokifuji, Hodaka Hayabuchi, Takashi Sasaki, Mariko Hara-Chikuma, Keiji Hirota, Hayato Takahashi, Masayuki Amagai, Akihiko Yoshimura, Shunsuke Chikuma (2023) Targeting abatacept-resistant T-helper-17 cells by aldehyde dehydrogenase inhibition iScience 108646
Inoue S, Noda S, Kashima K, Nakada K, Hayashi J, Miyoshi H. (2010) Mitochondrial respiration defects modulate differentiation but not proliferation of hematopoietic stem and progenitor cells. FEBS Lett 584(15) 3402-9
Wada H, Kojo S, Kusama C, Okamoto N, Sato Y, Ishizuka B, Seino K. (2011) Successful differentiation to T cells, but unsuccessful B-cell generation, from B-cell-derived induced pluripotent stem cells. Int Immunol 23(1) 65-74
Iwata A, Kawashima S, Kobayashi M, Okubo A, Kawashima H, Suto A, Hirose K, Nakayama T, Nakajima H. (2014) Th2-type inflammation instructs inflammatory dendritic cells to induce airway hyperreactivity. Int Immunol 26(2) 103-14
Matsumoto T, Sasaki N, Yamashita T, Emoto T, Kasahara K, Mizoguchi T, Hayashi T, Yodoi K, Kitano N, Saito T, Yamaguchi T, Hirata K. (2016) Overexpression of Cytotoxic T-Lymphocyte-Associated Antigen-4 Prevents Atherosclerosis in Mice. Arterioscler Thromb Vasc Biol 36(6) 1141-51
Uchiyama R, Yonehara S, Taniguchi S, Ishido S, Ishii KJ, Tsutsui H. (2017) Inflammasome and Fas-Mediated IL-1β Contributes to Th17/Th1 Cell Induction in Pathogenic Bacterial Infection In Vivo. J Immunol 199(3) 1122-1130
Kuroishi T, Bando K, Bakti RK, Ouchi G, Tanaka Y, Sugawara S. (2020) Migratory dendritic cells in skin-draining lymph nodes have nickel-binding capabilities. Sci Rep 10(1) 5050
Shimizu N, Noda S, Katayama K, Ichikawa H, Kodama H, Miyoshi H. (2008) Identification of genes potentially involved in supporting hematopoietic stem cell activity of stromal cell line MC3T3-G2/PA6. Int J Hematol 87(3) 239-45
Noda S, Horiguchi K, Ichikawa H, Miyoshi H. (2008) Repopulating activity of ex vivo-expanded murine hematopoietic stem cells resides in the CD48-c-Kit+Sca-1+lineage marker- cell population. Stem Cells 26(3) 646-55
Mise-Omata S, Kuroda E, Sugiura T, Yamashita U, Obata Y, Doi TS. (2009) The NF-kappaB RelA subunit confers resistance to Leishmania major by inducing nitric oxide synthase 2 and Fas expression but not Th1 differentiation. J Immunol 182(8) 4910-6
Masuko K, Wakita D, Togashi Y, Kita T, Kitamura H, Nishimura T. (2015) Artificially synthesized helper/killer-hybrid epitope long peptide (H/K-HELP): preparation and immunological analysis of vaccine efficacy. Immunol Lett 163(1) 102-12
Saijou E, Enomoto Y, Matsuda M, Yuet-Yin Kok C, Akira S, Tanaka M, Miyajima A. (2018) Neutrophils alleviate fibrosis in the CCl
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Category: targeted mutation
| Strain Name : |
B6.Cg-Tnc<tm1Sia>/Rbrc |
| Gene : |
Tnc,neo,lacZ |
| Species : |
Mus musculus |
| Disease : |
Neurobiology Research |
| Conditions for use : |
Live mouse (1 to 3 months),Cryopreserved sperm (within 1 month),Cryopreserved embryos (within 1 month) |
| Status : |
Live mice,Frozen embryos,Frozen sperm |
| Taxonomy : |
Mus musculus
|
| Reference : |
Imanaka-Yoshida K, Matsumoto K, Hara M, Sakakura T, Yoshida T. (2003) The dynamic expression of tenascin-C and tenascin-X during early heart development in the mouse. Differentiation 71(4-5) 291-8
Imanaka-Yoshida K, Matsumoto K, Hara M, Sakakura T, Yoshida T. (2003) The dynamic expression of tenascin-C and tenascin-X during early heart development in the mouse. Differentiation 71(4-5) 291-8
Nakamura-Ishizu A, Okuno Y, Omatsu Y, Okabe K, Morimoto J, Uede T, Nagasawa T, Suda T, Kubota Y. (2012) Extracellular matrix protein tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration. Blood 119(23) 5429-37
Nakamura-Ishizu A, Okuno Y, Omatsu Y, Okabe K, Morimoto J, Uede T, Nagasawa T, Suda T, Kubota Y. (2012) Extracellular matrix protein tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration. Blood 119(23) 5429-37
Xu M, Ye Z, Zhao X, Guo H, Gong X, Huang R. (2021) Deficiency of tenascin-C attenuated cardiac injury by inactivating TLR4/NLRP3/caspase-1 pathway after myocardial infarction. Cell Signal 86 110084
Xu M, Ye Z, Zhao X, Guo H, Gong X, Huang R. (2021) Deficiency of tenascin-C attenuated cardiac injury by inactivating TLR4/NLRP3/caspase-1 pathway after myocardial infarction. Cell Signal 86 110084
Kubo Y, Ishikawa K, Mori K, Kobayashi Y, Nakama T, Arima M, Nakao S, Hisatomi T, Haruta M, Sonoda KH, Yoshida S. (2020) Periostin and tenascin-C interaction promotes angiogenesis in ischemic proliferative retinopathy. Sci Rep 10(1) 9299
Kubo Y, Ishikawa K, Mori K, Kobayashi Y, Nakama T, Arima M, Nakao S, Hisatomi T, Haruta M, Sonoda KH, Yoshida S. (2020) Periostin and tenascin-C interaction promotes angiogenesis in ischemic proliferative retinopathy. Sci Rep 10(1) 9299
Matsumoto K, Takahashi K, Yoshiki A, Kusakabe M, Ariga H. (2002) Invasion of melanoma in double knockout mice lacking tenascin-X and tenascin-C. Jpn J Cancer Res 93(9) 968-75
Matsumoto K, Takahashi K, Yoshiki A, Kusakabe M, Ariga H. (2002) Invasion of melanoma in double knockout mice lacking tenascin-X and tenascin-C. Jpn J Cancer Res 93(9) 968-75
Ito K, Morimoto J, Kihara A, Matsui Y, Kurotaki D, Kanayama M, Simmons S, Ishii M, Sheppard D, Takaoka A, Uede T. (2014) Integrin α9 on lymphatic endothelial cells regulates lymphocyte egress. Proc Natl Acad Sci U S A 111(8) 3080-5
Ito K, Morimoto J, Kihara A, Matsui Y, Kurotaki D, Kanayama M, Simmons S, Ishii M, Sheppard D, Takaoka A, Uede T. (2014) Integrin α9 on lymphatic endothelial cells regulates lymphocyte egress. Proc Natl Acad Sci U S A 111(8) 3080-5
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Category: targeted mutation
| Strain Name : |
B6.129P2-Gfap<tm1Ito>/ItoRbrc |
| Gene : |
Gfap,neo,lacZ |
| Species : |
Mus musculus |
| Disease : |
Neurobiology Research |
| Conditions for use : |
Recovered litters from cryopreserved embryos (2 to 4 months),Cryopreserved sperm (within 1 month),Cryopreserved embryos (within 1 month) |
| Status : |
Frozen embryos,Frozen sperm |
| Taxonomy : |
Mus musculus
|
| Reference : |
Takizawa T, Gudla PR, Guo L, Lockett S, Misteli T. (2008) Allele-specific nuclear positioning of the monoallelically expressed astrocyte marker GFAP. Genes Dev 22(4) 489-98
Takizawa T, Gudla PR, Guo L, Lockett S, Misteli T. (2008) Allele-specific nuclear positioning of the monoallelically expressed astrocyte marker GFAP. Genes Dev 22(4) 489-98
|
Category: targeted mutation
| Strain Name : |
B6.Cg-Mak<tm1Yshk>/YshkRbrc |
| Gene : |
Mak,neo |
| Species : |
Mus musculus |
| Disease : |
Cell Biology Research |
| Conditions for use : |
Recovered litters from cryopreserved embryos (2 to 4 months),Cryopreserved sperm (within 1 month) |
| Status : |
Frozen embryos,Frozen sperm |
| Taxonomy : |
Mus musculus
|
| Reference : |
Omori Y, Chaya T, Katoh K, Kajimura N, Sato S, Muraoka K, Ueno S, Koyasu T, Kondo M, Furukawa T. (2010) Negative regulation of ciliary length by ciliary male germ cell-associated kinase (Mak) is required for retinal photoreceptor survival. Proc Natl Acad Sci U S A 107(52) 22671-6
Omori Y, Chaya T, Katoh K, Kajimura N, Sato S, Muraoka K, Ueno S, Koyasu T, Kondo M, Furukawa T. (2010) Negative regulation of ciliary length by ciliary male germ cell-associated kinase (Mak) is required for retinal photoreceptor survival. Proc Natl Acad Sci U S A 107(52) 22671-6
|
Category: targeted mutation
| Strain Name : |
B6.Cg-Aicda<tm1Hon> (N10)/HonRbrc |
| Gene : |
Aicda,loxP,neo |
| Species : |
Mus musculus |
| Disease : |
Cre/loxP system,Immunology and Inflammation Research |
| Conditions for use : |
Live mouse (1 to 3 months),Cryopreserved sperm (within 1 month),Cryopreserved embryos (within 1 month) |
| Status : |
Live mice,Frozen embryos,Frozen sperm |
| Taxonomy : |
Mus musculus
|
| Reference : |
Luo Y, Zhang X, Chen R, Li R, Liu Y, Zhang J, Liu Q, Si M, Liu J, Wu B, Wang X, Wu S, Zhang Y, Zhang X, Guo D, He X, Pan T, Zhang H. (2022) USP10 regulates B cell response to SARS-CoV-2 or HIV-1 nanoparticle vaccines through deubiquitinating AID. Signal Transduct Target Ther 7(1) 7
Luo Y, Zhang X, Chen R, Li R, Liu Y, Zhang J, Liu Q, Si M, Liu J, Wu B, Wang X, Wu S, Zhang Y, Zhang X, Guo D, He X, Pan T, Zhang H. (2022) USP10 regulates B cell response to SARS-CoV-2 or HIV-1 nanoparticle vaccines through deubiquitinating AID. Signal Transduct Target Ther 7(1) 7
Matsumoto M, Sasaki Y, Yasuda K, Takai T, Muramatsu M, Yoshimoto T, Nakanishi K. (2013) IgG and IgE collaboratively accelerate expulsion of Strongyloides venezuelensis in a primary infection. Infect Immun 81(7) 2518-27
Matsumoto M, Sasaki Y, Yasuda K, Takai T, Muramatsu M, Yoshimoto T, Nakanishi K. (2013) IgG and IgE collaboratively accelerate expulsion of Strongyloides venezuelensis in a primary infection. Infect Immun 81(7) 2518-27
Bello A, Müller A, Hirth G, Giebeler LN, Böttcher K, Voigt S, Jungnickel B. (2023) Cell Cycle-Mediated Regulation of Secondary Ig Diversification. J Immunol 210(10) 1508-1518
Bello A, Müller A, Hirth G, Giebeler LN, Böttcher K, Voigt S, Jungnickel B. (2023) Cell Cycle-Mediated Regulation of Secondary Ig Diversification. J Immunol 210(10) 1508-1518
Kato M, Tsuji-Kawahara S, Kawasaki Y, Kinoshita S, Chikaishi T, Takamura S, Fujisawa M, Kawada A, Miyazawa M. (2015) Class switch recombination and somatic hypermutation of virus-neutralizing antibodies are not essential for control of friend retrovirus infection. J Virol 89(2) 1468-73
Kato M, Tsuji-Kawahara S, Kawasaki Y, Kinoshita S, Chikaishi T, Takamura S, Fujisawa M, Kawada A, Miyazawa M. (2015) Class switch recombination and somatic hypermutation of virus-neutralizing antibodies are not essential for control of friend retrovirus infection. J Virol 89(2) 1468-73
|
Category: targeted mutation
| Strain Name : |
C.129S2-Pdcd1<tm1Hon>/HonRbrc (N12) |
| Gene : |
Pdcd1,neo |
| Species : |
Mus musculus |
| Disease : |
Immunology and Inflammation Research |
| Conditions for use : |
Live mouse (1 to 3 months),Cryopreserved sperm (within 1 month),Cryopreserved embryos (within 1 month) |
| Status : |
Live mice,Frozen embryos,Frozen sperm |
| Taxonomy : |
Mus musculus
|
| Reference : |
Ding ZC, Blazar BR, Mellor AL, Munn DH, Zhou G. (2010) Chemotherapy rescues tumor-driven aberrant CD4+ T-cell differentiation and restores an activated polyfunctional helper phenotype. Blood 115(12) 2397-406
Ding ZC, Blazar BR, Mellor AL, Munn DH, Zhou G. (2010) Chemotherapy rescues tumor-driven aberrant CD4+ T-cell differentiation and restores an activated polyfunctional helper phenotype. Blood 115(12) 2397-406
Ding ZC, Lu X, Yu M, Lemos H, Huang L, Chandler P, Liu K, Walters M, Krasinski A, Mack M, Blazar BR, Mellor AL, Munn DH, Zhou G. (2014) Immunosuppressive myeloid cells induced by chemotherapy attenuate antitumor CD4+ T-cell responses through the PD-1-PD-L1 axis. Cancer Res 74(13) 3441-53
Ding ZC, Lu X, Yu M, Lemos H, Huang L, Chandler P, Liu K, Walters M, Krasinski A, Mack M, Blazar BR, Mellor AL, Munn DH, Zhou G. (2014) Immunosuppressive myeloid cells induced by chemotherapy attenuate antitumor CD4+ T-cell responses through the PD-1-PD-L1 axis. Cancer Res 74(13) 3441-53
Ding ZC, Huang L, Blazar BR, Yagita H, Mellor AL, Munn DH, Zhou G. (2012) Polyfunctional CD4⁺ T cells are essential for eradicating advanced B-cell lymphoma after chemotherapy. Blood 120(11) 2229-39
Ding ZC, Huang L, Blazar BR, Yagita H, Mellor AL, Munn DH, Zhou G. (2012) Polyfunctional CD4⁺ T cells are essential for eradicating advanced B-cell lymphoma after chemotherapy. Blood 120(11) 2229-39
|
Category: targeted mutation
| Strain Name : |
C.Cg-Irf9<tm1Ttg>/TtgRbrc |
| Gene : |
Irf9,neo |
| Species : |
Mus musculus |
| Disease : |
Immunology and Inflammation Research |
| Conditions for use : |
Recovered litters from cryopreserved embryos (2 to 4 months) |
| Status : |
Frozen embryos |
| Taxonomy : |
Mus musculus
|
| Reference : |
Thibault DL, Chu AD, Graham KL, Balboni I, Lee LY, Kohlmoos C, Landrigan A, Higgins JP, Tibshirani R, Utz PJ. (2008) IRF9 and STAT1 are required for IgG autoantibody production and B cell expression of TLR7 in mice. J Clin Invest 118(4) 1417-26
Thibault DL, Chu AD, Graham KL, Balboni I, Lee LY, Kohlmoos C, Landrigan A, Higgins JP, Tibshirani R, Utz PJ. (2008) IRF9 and STAT1 are required for IgG autoantibody production and B cell expression of TLR7 in mice. J Clin Invest 118(4) 1417-26
Martinet V, Tonon S, Torres D, Azouz A, Nguyen M, Kohler A, Flamand V, Mao CA, Klein WH, Leo O, Goriely S. (2015) Type I interferons regulate eomesodermin expression and the development of unconventional memory CD8(+) T cells. Nat Commun 6 7089
Martinet V, Tonon S, Torres D, Azouz A, Nguyen M, Kohler A, Flamand V, Mao CA, Klein WH, Leo O, Goriely S. (2015) Type I interferons regulate eomesodermin expression and the development of unconventional memory CD8(+) T cells. Nat Commun 6 7089
|
Category: targeted mutation
| Strain Name : |
B6.129P2-Emx1<tm1.1(cre)Ito>/ItoRbrc |
| Gene : |
Emx1,nls,cre,Frt, |
| Species : |
Mus musculus |
| Disease : |
Cell Biology Research,Cre/loxP system,FLP/frt system,Neurobiology Research |
| Conditions for use : |
Live mouse (3 to 6 months),Cryopreserved sperm (within 1 month),Cryopreserved embryos (within 1 month) |
| Status : |
Live mice,Frozen embryos,Frozen sperm |
| Taxonomy : |
Mus musculus
|
| Reference : |
Nagashima S, Ito N, Kobayashi R, Shiiba I, Shimura H, Fukuda T, Hagihara H, Miyakawa T, Inatome R, Yanagi S. (2021) Forebrain-specific deficiency of the GTPase CRAG/Centaurin-γ3 leads to immature dentate gyri and hyperactivity in mice. J Biol Chem 296 100620
Nagashima S, Ito N, Kobayashi R, Shiiba I, Shimura H, Fukuda T, Hagihara H, Miyakawa T, Inatome R, Yanagi S. (2021) Forebrain-specific deficiency of the GTPase CRAG/Centaurin-γ3 leads to immature dentate gyri and hyperactivity in mice. J Biol Chem 296 100620
Sugimoto J, Tanaka M, Sugiyama K, Ito Y, Aizawa H, Soma M, Shimizu T, Mitani A, Tanaka K. (2018) Region-specific deletions of the glutamate transporter GLT1 differentially affect seizure activity and neurodegeneration in mice. Glia 66(4) 777-788
Sugimoto J, Tanaka M, Sugiyama K, Ito Y, Aizawa H, Soma M, Shimizu T, Mitani A, Tanaka K. (2018) Region-specific deletions of the glutamate transporter GLT1 differentially affect seizure activity and neurodegeneration in mice. Glia 66(4) 777-788
Nakata H, Hashimoto T, Seki Y, Mekada K, Obata Y, Yoshiki A. (2009) Simultaneous detection of multiple transgenes for genetically-modified mouse strains. Exp Anim 58(4) 437-42
Nakata H, Hashimoto T, Seki Y, Mekada K, Obata Y, Yoshiki A. (2009) Simultaneous detection of multiple transgenes for genetically-modified mouse strains. Exp Anim 58(4) 437-42
Sato T, Ishikawa M, Mochizuki M, Ohta M, Ohkura M, Nakai J, Takamatsu N, Yoshioka K. (2015) JSAP1/JIP3 and JLP regulate kinesin-1-dependent axonal transport to prevent neuronal degeneration. Cell Death Differ 22(8) 1260-74
Sato T, Ishikawa M, Mochizuki M, Ohta M, Ohkura M, Nakai J, Takamatsu N, Yoshioka K. (2015) JSAP1/JIP3 and JLP regulate kinesin-1-dependent axonal transport to prevent neuronal degeneration. Cell Death Differ 22(8) 1260-74
Takagi T, Nishizaki Y, Matsui F, Wakamatsu N, Higashi Y. (2015) De novo inbred heterozygous Zeb2/Sip1 mutant mice uniquely generated by germ-line conditional knockout exhibit craniofacial, callosal and behavioral defects associated with Mowat-Wilson syndrome. Hum Mol Genet 24(22) 6390-402
Takagi T, Nishizaki Y, Matsui F, Wakamatsu N, Higashi Y. (2015) De novo inbred heterozygous Zeb2/Sip1 mutant mice uniquely generated by germ-line conditional knockout exhibit craniofacial, callosal and behavioral defects associated with Mowat-Wilson syndrome. Hum Mol Genet 24(22) 6390-402
Mizusawa A, Watanabe A, Yamada M, Kamei R, Shimomura Y, Kitaura Y. (2020) BDK Deficiency in Cerebral Cortex Neurons Causes Neurological Abnormalities and Affects Endurance Capacity. Nutrients 12(8)
Mizusawa A, Watanabe A, Yamada M, Kamei R, Shimomura Y, Kitaura Y. (2020) BDK Deficiency in Cerebral Cortex Neurons Causes Neurological Abnormalities and Affects Endurance Capacity. Nutrients 12(8)
|
Category: spontaneous mutation
| Strain Name : |
C57BL/6-Prkdc<scid>/Rbrc |
| Gene : |
Prkdc |
| Species : |
Mus musculus |
| Disease : |
Immunology and Inflammation Research |
| Conditions for use : |
Recovered litters from cryopreserved sperm (2 to 4 months),Cryopreserved sperm (within 1 month) |
| Status : |
Frozen embryos,Frozen sperm |
| Taxonomy : |
Mus musculus
|
| Reference : |
Ishino T, Kawashima S, Tanji E, Ueno T, Ueda Y, Ogasawara S, Sato K, Mano H, Ishihara S, Kato N, Kawazu M, Togashi Y. (2023) Somatic mutations can induce a noninflamed tumour microenvironment via their original gene functions, despite deriving neoantigens. Br J Cancer
Ishino T, Kawashima S, Tanji E, Ueno T, Ueda Y, Ogasawara S, Sato K, Mano H, Ishihara S, Kato N, Kawazu M, Togashi Y. (2023) Somatic mutations can induce a noninflamed tumour microenvironment via their original gene functions, despite deriving neoantigens. Br J Cancer
Kawase K, Kawashima S, Nagasaki J, Inozume T, Tanji E, Kawazu M, Hanazawa T, Togashi Y. (2023) High Expression of MHC Class I Overcomes Cancer Immunotherapy Resistance Due to IFNγ Signaling Pathway Defects. Cancer Immunol Res OF1-OF14
Kawase K, Kawashima S, Nagasaki J, Inozume T, Tanji E, Kawazu M, Hanazawa T, Togashi Y. (2023) High Expression of MHC Class I Overcomes Cancer Immunotherapy Resistance Due to IFNγ Signaling Pathway Defects. Cancer Immunol Res OF1-OF14
Kemmotsu N, Zhu L, Nagasaki J, Otani Y, Ueda Y, Dansako H, Fang Y, Date I, Togashi Y. (2023) Combination therapy with hydrogen peroxide and irradiation promotes an abscopal effect in mouse models. Cancer Sci
Kemmotsu N, Zhu L, Nagasaki J, Otani Y, Ueda Y, Dansako H, Fang Y, Date I, Togashi Y. (2023) Combination therapy with hydrogen peroxide and irradiation promotes an abscopal effect in mouse models. Cancer Sci
Nagasaki J, Togashi Y, Sugawara T, Itami M, Yamauchi N, Yuda J, Sugano M, Ohara Y, Minami Y, Nakamae H, Hino M, Takeuchi M, Nishikawa H. (2020) The critical role of CD4+ T cells in PD-1 blockade against MHC-II-expressing tumors such as classic Hodgkin lymphoma. Blood Adv 4(17) 4069-4082
Nagasaki J, Togashi Y, Sugawara T, Itami M, Yamauchi N, Yuda J, Sugano M, Ohara Y, Minami Y, Nakamae H, Hino M, Takeuchi M, Nishikawa H. (2020) The critical role of CD4+ T cells in PD-1 blockade against MHC-II-expressing tumors such as classic Hodgkin lymphoma. Blood Adv 4(17) 4069-4082
|
Category: targeted mutation
| Strain Name : |
B6.129S4-Tob1<tm1Tya>/TyaRbrc |
| Gene : |
Tob1,neo |
| Species : |
Mus musculus |
| Conditions for use : |
Recovered litters from cryopreserved embryos (2 to 4 months),Cryopreserved embryos (within 1 month) |
| Status : |
Frozen embryos,Frozen sperm |
| Taxonomy : |
Mus musculus
|
| Reference : |
Schulze-Topphoff U, Casazza S, Varrin-Doyer M, Pekarek K, Sobel RA, Hauser SL, Oksenberg JR, Zamvil SS, Baranzini SE. (2013) Tob1 plays a critical role in the activation of encephalitogenic T cells in CNS autoimmunity. J Exp Med 210(7) 1301-9
Schulze-Topphoff U, Casazza S, Varrin-Doyer M, Pekarek K, Sobel RA, Hauser SL, Oksenberg JR, Zamvil SS, Baranzini SE. (2013) Tob1 plays a critical role in the activation of encephalitogenic T cells in CNS autoimmunity. J Exp Med 210(7) 1301-9
Didonna A, Cekanaviciute E, Oksenberg JR, Baranzini SE. (2016) Immune cell-specific transcriptional profiling highlights distinct molecular pathways controlled by Tob1 upon experimental autoimmune encephalomyelitis. Sci Rep 6 31603
Didonna A, Cekanaviciute E, Oksenberg JR, Baranzini SE. (2016) Immune cell-specific transcriptional profiling highlights distinct molecular pathways controlled by Tob1 upon experimental autoimmune encephalomyelitis. Sci Rep 6 31603
|
Category: congenic strain
| Strain Name : |
B6.CS-Ngu1053 |
| Gene : |
Ngu1053 |
| Species : |
Mus musculus |
| Conditions for use : |
Recovered litters from cryopreserved embryos (2 to 4 months),Cryopreserved sperm (within 1 month),Cryopreserved embryos (within 1 month) |
| Status : |
Frozen embryos,Frozen sperm |
| Taxonomy : |
Mus musculus
|
| Reference : |
Tomida S, Mamiya T, Sakamaki H, Miura M, Aosaki T, Masuda M, Niwa M, Kameyama T, Kobayashi J, Iwaki Y, Imai S, Ishikawa A, Abe K, Yoshimura T, Nabeshima T, Ebihara S. (2009) Usp46 is a quantitative trait gene regulating mouse immobile behavior in the tail suspension and forced swimming tests. Nat Genet 41(6) 688-95
|
Category: spontaneous mutation
| Strain Name : |
C57BL/6-W<sh>/W<sh> |
| Gene : |
Kit |
| Species : |
Mus musculus |
| Disease : |
Dermatology Research,Immunology and Inflammation Research |
| Conditions for use : |
Live mouse (1 to 3 months),Cryopreserved sperm (within 1 month),Cryopreserved embryos (within 1 month) |
| Status : |
Live mice,Frozen embryos,Frozen sperm |
| Taxonomy : |
Mus musculus
|
| Reference : |
Hitomi K, Tahara-Hanaoka S, Miki H, Iwata K, Shibayama S, Kubo M, Shibuya A. (2018) Allergin-1 on mast cells suppresses house dust mite-induced airway hyperresponsiveness in mice. Int Immunol 30(9) 429-434
Hitomi K, Tahara-Hanaoka S, Miki H, Iwata K, Shibayama S, Kubo M, Shibuya A. (2018) Allergin-1 on mast cells suppresses house dust mite-induced airway hyperresponsiveness in mice. Int Immunol 30(9) 429-434
Nakamura T, Maeda S, Horiguchi K, Maehara T, Aritake K, Choi BI, Iwakura Y, Urade Y, Murata T. (2015) PGD2 deficiency exacerbates food antigen-induced mast cell hyperplasia. Nat Commun 6 7514
Nakamura T, Maeda S, Horiguchi K, Maehara T, Aritake K, Choi BI, Iwakura Y, Urade Y, Murata T. (2015) PGD2 deficiency exacerbates food antigen-induced mast cell hyperplasia. Nat Commun 6 7514
Yoshida K, Tanihara S, Miyashita Y, Obayashi K, Ito MA, Yamamoto K, Imai T, Matsuoka I. (2022) P2X4 receptor stimulation enhances MrgprB2-mediated mast cell activation and pseudoallergic reactions in mice. Sci Rep 12(1) 18613
Yoshida K, Tanihara S, Miyashita Y, Obayashi K, Ito MA, Yamamoto K, Imai T, Matsuoka I. (2022) P2X4 receptor stimulation enhances MrgprB2-mediated mast cell activation and pseudoallergic reactions in mice. Sci Rep 12(1) 18613
Murata T, Aritake K, Matsumoto S, Kamauchi S, Nakagawa T, Hori M, Momotani E, Urade Y, Ozaki H. (2011) Prostagladin D2 is a mast cell-derived antiangiogenic factor in lung carcinoma. Proc Natl Acad Sci U S A 108(49) 19802-7
Murata T, Aritake K, Matsumoto S, Kamauchi S, Nakagawa T, Hori M, Momotani E, Urade Y, Ozaki H. (2011) Prostagladin D2 is a mast cell-derived antiangiogenic factor in lung carcinoma. Proc Natl Acad Sci U S A 108(49) 19802-7
Ohneda K, Moriguchi T, Ohmori S, Ishijima Y, Satoh H, Philipsen S, Yamamoto M. (2014) Transcription factor GATA1 is dispensable for mast cell differentiation in adult mice. Mol Cell Biol 34(10) 1812-26
Ohneda K, Moriguchi T, Ohmori S, Ishijima Y, Satoh H, Philipsen S, Yamamoto M. (2014) Transcription factor GATA1 is dispensable for mast cell differentiation in adult mice. Mol Cell Biol 34(10) 1812-26
Iwanaga K, Nakamura T, Maeda S, Aritake K, Hori M, Urade Y, Ozaki H, Murata T. (2014) Mast cell-derived prostaglandin D2 inhibits colitis and colitis-associated colon cancer in mice. Cancer Res 74(11) 3011-9
Iwanaga K, Nakamura T, Maeda S, Aritake K, Hori M, Urade Y, Ozaki H, Murata T. (2014) Mast cell-derived prostaglandin D2 inhibits colitis and colitis-associated colon cancer in mice. Cancer Res 74(11) 3011-9
Schuler P, Contassot E, Irla M, Hugues S, Preynat-Seauve O, Beermann F, Donda A, French LE, Huard B. (2008) Direct presentation of a melanocyte-associated antigen in peripheral lymph nodes induces cytotoxic CD8+ T cells. Cancer Res 68(20) 8410-8
Schuler P, Contassot E, Irla M, Hugues S, Preynat-Seauve O, Beermann F, Donda A, French LE, Huard B. (2008) Direct presentation of a melanocyte-associated antigen in peripheral lymph nodes induces cytotoxic CD8+ T cells. Cancer Res 68(20) 8410-8
Nakahashi-Oda C, Tahara-Hanaoka S, Shoji M, Okoshi Y, Nakano-Yokomizo T, Ohkohchi N, Yasui T, Kikutani H, Honda S, Shibuya K, Nagata S, Shibuya A. (2012) Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor. J Exp Med 209(8) 1493-503
Nakahashi-Oda C, Tahara-Hanaoka S, Shoji M, Okoshi Y, Nakano-Yokomizo T, Ohkohchi N, Yasui T, Kikutani H, Honda S, Shibuya K, Nagata S, Shibuya A. (2012) Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor. J Exp Med 209(8) 1493-503
Murata A, Hikosaka M, Yoshino M, Zhou L, Hayashi SI. (2019) Kit-independent mast cell adhesion mediated by Notch. Int Immunol 31(2) 69-79
Murata A, Hikosaka M, Yoshino M, Zhou L, Hayashi SI. (2019) Kit-independent mast cell adhesion mediated by Notch. Int Immunol 31(2) 69-79
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