 Tabs(ALL, DNA, BLAST, GO, Taxonomy, DO, Reference) are clickable.
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Resource count: 6,594,866
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Resource Information
Strain No :
RBRC01351
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| Organism |
Mice |
| strain or clone |
Strain |
| Category |
targeted mutation |
| Resource name |
RBRC01351 |
| Availability |
Available
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| Features |
| Strain Name : |
B6.129S-Grm2<tm1Nak>/NakRbrc |
| Gene : |
Grm2,neo |
| Species : |
Mus musculus |
| Disease : |
Neurobiology Research |
| Conditions for use : |
Recovered litters from cryopreserved embryos (2 to 4 months),Cryopreserved sperm (within 1 month),Cryopreserved embryos (within 1 month) |
| Status : |
Frozen embryos,Frozen sperm |
| Taxonomy : |
Mus musculus
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| Reference : |
Moreno JL, Holloway T, Albizu L, Sealfon SC, González-Maeso J. (2011) Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists. Neurosci Lett 493(3) 76-9
Moreno JL, Holloway T, Albizu L, Sealfon SC, González-Maeso J. (2011) Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists. Neurosci Lett 493(3) 76-9
Moreno JL, Muguruza C, Umali A, Mortillo S, Holloway T, Pilar-Cuéllar F, Mocci G, Seto J, Callado LF, Neve RL, Milligan G, Sealfon SC, López-Giménez JF, Meana JJ, Benson DL, González-Maeso J. (2012) Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A·mGlu2) receptor heteromerization and its psychoactive behavioral function. J Biol Chem 287(53) 44301-19
Moreno JL, Muguruza C, Umali A, Mortillo S, Holloway T, Pilar-Cuéllar F, Mocci G, Seto J, Callado LF, Neve RL, Milligan G, Sealfon SC, López-Giménez JF, Meana JJ, Benson DL, González-Maeso J. (2012) Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A·mGlu2) receptor heteromerization and its psychoactive behavioral function. J Biol Chem 287(53) 44301-19
Fribourg M, Moreno JL, Holloway T, Provasi D, Baki L, Mahajan R, Park G, Adney SK, Hatcher C, Eltit JM, Ruta JD, Albizu L, Li Z, Umali A, Shim J, Fabiato A, MacKerell AD Jr, Brezina V, Sealfon SC, Filizola M, González-Maeso J, Logothetis DE. (2011) Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs. Cell 147(5) 1011-23
Fribourg M, Moreno JL, Holloway T, Provasi D, Baki L, Mahajan R, Park G, Adney SK, Hatcher C, Eltit JM, Ruta JD, Albizu L, Li Z, Umali A, Shim J, Fabiato A, MacKerell AD Jr, Brezina V, Sealfon SC, Filizola M, González-Maeso J, Logothetis DE. (2011) Decoding the signaling of a GPCR heteromeric complex reveals a unifying mechanism of action of antipsychotic drugs. Cell 147(5) 1011-23
Moreno JL, Holloway T, Rayannavar V, Sealfon SC, González-Maeso J. (2013) Chronic treatment with LY341495 decreases 5-HT(2A) receptor binding and hallucinogenic effects of LSD in mice. Neurosci Lett 536 69-73
Moreno JL, Holloway T, Rayannavar V, Sealfon SC, González-Maeso J. (2013) Chronic treatment with LY341495 decreases 5-HT(2A) receptor binding and hallucinogenic effects of LSD in mice. Neurosci Lett 536 69-73
Moreno JL, Miranda-Azpiazu P, García-Bea A, Younkin J, Cui M, Kozlenkov A, Ben-Ezra A, Voloudakis G, Fakira AK, Baki L, Ge Y, Georgakopoulos A, Morón JA, Milligan G, López-Giménez JF, Robakis NK, Logothetis DE, Meana JJ, González-Maeso J. (2016) Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia. Sci Signal 9(410) ra5
Moreno JL, Miranda-Azpiazu P, García-Bea A, Younkin J, Cui M, Kozlenkov A, Ben-Ezra A, Voloudakis G, Fakira AK, Baki L, Ge Y, Georgakopoulos A, Morón JA, Milligan G, López-Giménez JF, Robakis NK, Logothetis DE, Meana JJ, González-Maeso J. (2016) Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia. Sci Signal 9(410) ra5
Kim H, Lee Y, Park JY, Kim JE, Kim TK, Choi J, Lee JE, Lee EH, Kim D, Kim KS, Han PL. (2017) Loss of Adenylyl Cyclase Type-5 in the Dorsal Striatum Produces Autistic-Like Behaviors. Mol Neurobiol 54(10) 7994-8008
Kim H, Lee Y, Park JY, Kim JE, Kim TK, Choi J, Lee JE, Lee EH, Kim D, Kim KS, Han PL. (2017) Loss of Adenylyl Cyclase Type-5 in the Dorsal Striatum Produces Autistic-Like Behaviors. Mol Neurobiol 54(10) 7994-8008
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Resouce detail information
(request form)
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http://www2.brc.riken.jp/lab/animal/detail.php?brc_no=RBRC01351
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| Organization |
Experimental Animal Division, RIKEN BioResource Research Center |
| Person in charge |
YOSHIKI Atsushi |
| Postal Code |
305-0074 |
| Address |
3-1-1 Koyadai, Tsukuba, Ibaraki, Japan |
| Phone |
029-836-5264 |
| FAX |
029-836-9010 |
| E-mail |
animal@brc.riken.jp
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| URL |
https://mus.brc.riken.jp
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| Other information |
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