系統情報
 NBRP Rat No: 0729  系統名: LEW.WKY-(D13Arb15-D13Rat77)(D16Rat40-D16Rat88)/Tja  通称: LEW.WCrgn1,2 Rat Genome Database
研究責任者:  Timothy J. Aitman         Medical Research Council        〒W12 0NN  London Hammersmith Hospital campus, Du Cane Road       United Kingdom
Tel: +44 20 8383 4253    Fax: +44 20 8383 8577 Email: t.aitman@csc.mrc.ac.uk
保存状況：   胚            精子           生体
毛色  Albino
近交世代数  
利用条件  研究成果の公表にあたって寄託者の指定する文献を引用する。

D'Souza Z., McAdoo S.P., Smoth J., Pusey C.D., Cook H.T., Behmoaras J., Aitman T.J. (2013) Experimental crescentic glomerulonephritis: a new bicongenic rat model. Disease Models and Mechanisms.
分類
 Inbred  Segregating  Congenic  Consomic  Recombinant
 Coisogenic  Spont. Mutant  Transgene  Ind. Mutant  その他 
コマーシャルブリーダー
研究分野
 糖尿病・肥満  脳神経疾患  眼疾患  歯科疾患  循環器系疾患・高血圧
 がん・腫瘍  代謝、内分泌  耳鼻疾患  免疫・アレルギー疾患  感染症
 骨形態異常  消化器疾患  皮膚疾患  生殖器疾患  発生
 行動・学習  血液疾患  泌尿器疾患  薬理学  その他  
 対照動物  レポーター遺伝子動物
遺伝子 Lewis bicongenic (chromosomes 13 and 16)
由来 LEWIS: Lewis from Wistar stock, to Aptekman and Bogden 1954 at F20, to SIlvers 1958 at F31. Subsequently distributed by Silvers.
特性など Development of glomerular crescents, a hallmark of crescentic glomerulonephritis (CRGN) after the induction of nephrotoxic serum in this Lewis-related bicongenic strain, compared to parental Lewis strain which is resistant to CRGN.
繁殖・維持方法 No special needs. Good breeding performance, 6-8 litters, normal diet, water acidification, no supplements, no medications.
遺伝診断法 Microsatellite markers used for genotyping. Chromosome 13: Congenic locus spans between D13Arb15 to D13Rat77 Chromosome 16: Congenic locus spans between D16Rat40 to D16Rat88
参考文献 D'Souza et al (2013) Experimental crescentic glomerulonephritis: a new bicongenic rat model. Disease Models and Mechanisms.

Aitman et al (2006) Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans. Nature. 2006 Feb 16;439(7078):851-5.

Behmoaras et al (2008) Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility. Nat Genet. 2008 May;40(5):553-9. doi: 10.1038/ng.137.
系統情報