Strain Name: cacnb1 / Allele: mi90

Allele mi90
Strain Name cacnb1
Type Mutant
Genotype cacnb1mi90/mi90
Affected Gene cacnb1(Cacnb1)
Origin and Depositor National Institute of Genetics (Hiromi Hirata)
Link to ZFIN ZDB-GENO-060313-1    
Information
The cacnb1 mutants are called relaxed mutants.The mutant phenotype results from a non-sense mutation in the zebrafish cacnb1 gene that encodes the voltage-gated calcium channel beta1 subunit. The zebrafish cacnb1 gene is expressed in skeletal muscles, PNS and CNS. The mutants are immotile due to a defect in excitation-contraction coupling of skeletal muscle.  
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Reference

Zhou W, Saint-Amant L, Hirata H, Cui WW, Sprague SM, Kuwada JY. Non-sense mutations in the dihydropyridine receptor beta1 gene, CACNB1, paralyze zebrafish relaxed mutants. Cell Calcium. 2006 ; 39(3) : 227-236 .

 
Facility RIKEN Center for Brain Science