 Tabs(ALL, DNA, BLAST, GO, Taxonomy, DO, Reference) are clickable.
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Resource count: 6,595,109
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Resource Information
Strain No :
RBRC00344
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| Organism |
Mice |
| strain or clone |
Strain |
| Category |
transgenic mutation |
| Resource name |
RBRC00344 |
| Availability |
Available
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| Features |
| Strain Name : |
B6D2-Tg(CAG-AR*97Q)7-8Sobu |
| Gene : |
Tg(CAG-AR*97Q)7-8Sobu,AR |
| Species : |
Mus musculus |
| Conditions for use : |
Recovered litters from cryopreserved embryos (2 to 4 months),Cryopreserved sperm (within 1 month),Cryopreserved embryos (within 1 month) |
| Status : |
Frozen embryos,Frozen sperm |
| Taxonomy : |
Mus musculus
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| Reference : |
Adachi H, Katsuno M, Minamiyama M, Waza M, Sang C, Nakagomi Y, Kobayashi Y, Tanaka F, Doyu M, Inukai A, Yoshida M, Hashizume Y, Sobue G. (2005) Widespread nuclear and cytoplasmic accumulation of mutant androgen receptor in SBMA patients. Brain 128(Pt 3) 659-70
Minamiyama M, Katsuno M, Adachi H, Waza M, Sang C, Kobayashi Y, Tanaka F, Doyu M, Inukai A, Sobue G. (2004) Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy. Hum Mol Genet 13(11) 1183-92
Katsuno M, Adachi H, Tanaka F, Sobue G. (2004) Spinal and bulbar muscular atrophy: ligand-dependent pathogenesis and therapeutic perspectives. J Mol Med (Berl) 82(5) 298-307
Katsuno M, Adachi H, Inukai A, Sobue G. (2003) Transgenic mouse models of spinal and bulbar muscular atrophy (SBMA). Cytogenet Genome Res 100(1-4) 243-51
Ishihara K, Yamagishi N, Saito Y, Adachi H, Kobayashi Y, Sobue G, Ohtsuka K, Hatayama T. (2003) Hsp105alpha suppresses the aggregation of truncated androgen receptor with expanded CAG repeats and cell toxicity. J Biol Chem 278(27) 25143-50
Katsuno M, Adachi H, Kume A, Li M, Nakagomi Y, Niwa H, Sang C, Kobayashi Y, Doyu M, Sobue G. (2002) Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy. Neuron 35(5) 843-54
Katsuno M, Adachi H, Doyu M, Minamiyama M, Sang C, Kobayashi Y, Inukai A, Sobue G. (2003) Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy. Nat Med 9(6) 768-73
Adachi H, Katsuno M, Minamiyama M, Sang C, Pagoulatos G, Angelidis C, Kusakabe M, Yoshiki A, Kobayashi Y, Doyu M, Sobue G. (2003) Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein. J Neurosci 23(6) 2203-11
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Resouce detail information
(request form)
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http://www2.brc.riken.jp/lab/animal/detail.php?brc_no=RBRC00344
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| Organization |
Experimental Animal Division, RIKEN BioResource Research Center |
| Person in charge |
YOSHIKI Atsushi |
| Postal Code |
305-0074 |
| Address |
3-1-1 Koyadai, Tsukuba, Ibaraki, Japan |
| Phone |
029-836-5264 |
| FAX |
029-836-9010 |
| E-mail |
animal@brc.riken.jp
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| URL |
https://mus.brc.riken.jp
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| Other information |
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